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XB-ART-964
Development January 1, 2006; 133 (2): 209-16.

GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos.

Levine AJ , Brivanlou AH .


Abstract
The TGFbeta superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily, blocks classic BMP signaling in multiple contexts, interacts with BMP proteins and is expressed specifically in the node during gastrulation in a pattern consistent with BMP inhibition. Furthermore, we use gain- and reduction-of-function to show that in a species-specific manner, GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.

PubMed ID: 16339188
Article link: Development
Grant support: [+]
Genes referenced: actb actl6a babam2 bmp4 fgf5 gdf3 hprt1 kdr lif mrc1 msx1 ncam1 nkx2-5 odc1 pax6 pou5f3.1 ppib rax smad1 smad2 smad4.1 smad4.2 sox2 tbxt tgfb1 znf423
Antibodies: Gdf3 Ab1 Smad1 Ab5 Smad2 Ab3


Article Images: [+] show captions


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