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XB-ART-9767
Cell. December 8, 2000; 103 (6): 885-96.

Crystal structure of a beta-catenin/Tcf complex.

Graham TA , Weaver C , Mao F , Kimelman D , Xu W .


Abstract
The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.

PubMed ID: 11136974
Article link: Cell.
Grant support: GM07270 NIGMS NIH HHS , HD07183 NICHD NIH HHS , HD27262 NICHD NIH HHS

Genes referenced: tcf3
Antibodies referenced:

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