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XB-ART-9833
Biochim Biophys Acta 2000 Dec 11;14991-2:164-170. doi: 10.1016/s0167-4889(00)00083-5.
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Molecular cloning and expression profile of Xenopus calcineurin A subunit(1).

Saneyoshi T , Kume S , Natsume T , Mikoshiba K .


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We have cloned a cDNA encoding a catalytic subunit of calcineurin (CnA) expressed in Xenopus oocytes. The deduced amino acid sequence indicates 96.3% and 96.8% identities with the mouse and human CnAalpha isoforms, respectively. Xenopus CnA (XCnA) RNA and protein are expressed as maternal and throughout development. Recombinant XCnA protein interacted with calmodulin in the presence of Ca(2+). Deletion of calmodulin binding domain and auto-inhibitory domain revealed calcium independent phosphatase activity, thereby showing that XCnA is likely to be modulated by both calmodulin and calcium.

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Species referenced: Xenopus
Genes referenced: ppp3ca