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Summary Images Attributions Wiki Source
XB-ANTIBODY-14579213

Antibody Name: Tpm1 Ab1

Common Name: tropomyosin

RRID: AB_2205770
Synonyms: CH1, Tmy

Antigens
Gene: tpm1
XAO: heart, muscle

Clone Type: Monoclonal
Source: Developmental Studies Hybridoma Bank

Antibody
Clone Number CH1
Purification
Isotype IgG1
Host Organism mouse
Xenopus Reactivity tropicalis, laevis
Non-Xenopus Reactivity chicken, human, mouse, rat, zebrafish
Description: Supplied by DSHB, Cat# CH1. Citation: (DSHB Cat# CH1, RRID:AB_2205770). Please email citation to DSHB.
Immunogen
Name muscle tropomyosin
Type polypeptide
Post Translational Modifications None
Source Organism chicken
Description chicken muscle tropomyosin CH1 reacts strongly with striated muscle forms of tropomyosin, including cardiac alpha-tropomyosin and skeletal alpha- and beta-tropomyosins, but not with tropomyosin isoforms from gizzard (smooth muscle) or chicken embryo fibroblasts. CH1 interferes with the binding of tropomyosin to actin. CH1 recognizes sarcomeric Tm soforms alpha-fast, beta, and alpha-slow with poor affinity for alpha-slow.
Sequence [+]
Reported Usage
western blot
immunoprecipitation
immunofluorescence Fix with Dents or PFA
enzyme-linked immunosorbent assay
Publications
First: Monoclonal antibodies against chicken tropomyosin isoforms: production, characterization, and application., Hybridoma 1985  
Most recent: Spatiotemporally Controlled Mechanical Cues Drive Progenitor Mesenchymal-to-Epithelial Transition Enabling Proper Heart Formation and Function., Curr Biol 2017                              
View All Papers

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