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XB-ANTIBODY-18328526

Antibody Name: Hist1H3A Ab2

Common Name:

RRID: AB_2616029
Synonyms: 9733, H3/A, H3FA

Antigens

Clone Type: Monoclonal
Source: Cell Signaling Technology

Antibody
Clone Number
Purification
Isotype IgG
Host Organism rabbit
Xenopus Reactivity tropicalis, laevis
Non-Xenopus Reactivity
Description: Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb detects endogenous levels of histone H3 only when tri-methylated on Lys27. The antibody does not cross-react with non-methylated, mono-methylated or di-methylated Lys27. In addition, the antibody does not cross-react with mono-methylated, di-methylated or tri-methylated histone H3 at Lys4, Lys9, Lys36 or Histone H4 at Lys20. NOn-mamalian species predicted to react based on 100% sequence homology: Xenopus, Zebrafish
Immunogen
Name Histone H3
Type polypeptide
Post Translational Modifications Methylated
Source Organism rabbit
Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of histone H3 in which Lys27 is tri-methylated.
Sequence
Reported Usage
chromatin immunoprecipitation
Publications
First: Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways., Mol Cell 2017                                        
Most recent: Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription., Nat Commun 2020                
View All Papers