XB-LINE-1427
Line Name: Xla.pkd1em2Horb
| Summary |
|
| Synonym: |
Xla.pkd1tmHorb |
| Species: |
Xenopus laevis |
| Background Strain: |
Xla.J-strainNXR
|
| Description: |
CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line transmission confirmed. Animals carry a 281 base pair deletion. Contact the NXR for more details. Custom mutant generated by Horb Lab. |
| Phenotype Description: |
-281 base pair mutation sequence ATGTTGTTGGGTTA----(281)--- ATAATTA. Embryos develop abnormal kidneys (dilated tubules appear after stage 40), cystic kidneys in F0s. Associated with human autosomal dominant polycystic kidney disease. |
| Color Morph: |
pigmented |
| Breeding Type: |
OUTBRED
|
| Lab of Origin: |
Horb Lab |
| Line Type: |
Mutant |
| Mutated Gene(s): |
pkd1.L
|
| MTA Required: |
No
|
| Public: |
Yes
|
| Catalog Number: |
NXR_2170 |
| Stock Center |
RRID |
Generation |
DOB |
# Males |
# Females |
Availability |
Mutant Details |
| NXR (US) |
NXR_2170 |
F1 |
|
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