XB-LINE-1539
Line Name: Xtr.oc90mZimml
| Summary |
|
| Synonym: |
Komimi, kommh62, T269-C, kom |
| Species: |
Xenopus tropicalis |
| Background Strain: |
Xtr.Nigerian1EXRC
|
| Description: |
Mutation affecting inner ear otoconia identified in the Mill Hill screen for ENU-induced mutations. Mutation in the otoconin90 gene. Reference: Ironfield, H.V.; (2011) Genetic studies of inner ear development in Xenopus tropicalis. Doctoral thesis. http://discovery.ucl.ac.uk/1324536/ |
| Phenotype Description: |
Homozygous tadpoles display balance defects and inner ear defects in otoconial formation. At NF stage 45, kom tadpoles show a single enlarged otoconium located over each inner ear macula sensory epithelium. Hair cell deficits ensue, and tadpoles display vestibular behavioural defects such as circular swimming. |
| Color Morph: |
pigmented |
| Breeding Type: |
OUTBRED
|
| Lab of Origin: |
Zimmerman Lab |
| Line Type: |
Mutant |
| Mutated Gene(s): |
oc90
|
| MTA Required: |
Yes
|
| Public: |
Yes
|
|
Xtr.oc90 mutant tadpoles ( phenotype called komimi /kom) develop single large aggregated otoconia over the saccular and utricular maculae. Hair cell deficits ensue, and tadpoles display vestibular behavioural defects such as circular swimming
|
|
Xtr.oc90 mutant tadpoles ( phenotype called komimi /kom) develop single large aggregated otoconia over the saccular and utricular maculae. Hair cell deficits ensue, and tadpoles display vestibular behavioural defects such as circular swimming
|
| Stock Center |
RRID |
Generation |
DOB |
# Males |
# Females |
Availability |
Mutant Details |
| EXRC (Europe) |
EXRC_6006 |
|
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