| Summary |
|
| Synonym: |
hsp70:dnTead4-2A-GFP, gCry:tdTomato |
| Species: |
Xenopus laevis |
| Background Strain: |
Xla.Outbred
|
| Paternal Line: |
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| Maternal Line: |
|
| Description: |
330bp of promoter of the X. laevis hsp70 gene driving expression dominant negative form of tead4 (DNtead4) tagged with GFP via 2A peptides, and 2.2 kb gamma crystalline promoter driving tdTomato.
dnTead4 (labeled withGFP) specifically blockes tead4 function in Hippo signaling and DNTead4-2A-GFP expression can be induced at a specific time-point by a heat-shock in this transgenic Xenopus. Thus, you can block tead4 function temporally at a desired time-point, by heat-shock.
|
| Phenotype Description: |
DNtead4-2A-GFP can be induced by a heat-shock; the tdTomato (red) fluorescence in the lens. |
| Color Morph: |
|
| Breeding Type: |
UNKNOWN
|
| Lab of Origin: |
Tamura Lab |
| Line Type: |
Transgenic |
| Mutated Gene(s): |
|
| MTA Required: |
No
|
| Public: |
Yes
|
| Catalogue Number: |
EXRC line #81,waiting for EXRC RRID number |
