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The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease. , Manning JA., Cell Death Dis. April 14, 2021; 12 (4): 398.
Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis. , Ilyaskin AV., J Biol Chem. January 1, 2021; 296 100404.
Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis. , Lokapally A., Cells. July 20, 2020; 9 (7):
β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. , Ho PY., J Biol Chem. July 20, 2018; 293 (29): 11612-11624.
Regulation of Kv1.4 potassium channels by PKC and AMPK kinases. , Andersen MN., Channels (Austin). January 1, 2018; 12 (1): 34-44.
Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. , Wilkars W., FASEB J. May 1, 2014; 28 (5): 2177-90.
The Nedd4-binding protein 3 ( N4BP3) is crucial for axonal and dendritic branching in developing neurons. , Schmeisser MJ., Neural Dev. September 17, 2013; 8 18.
WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. , Yu L., Am J Physiol Renal Physiol. July 1, 2013; 305 (1): F31-41.
AMP-activated protein kinase downregulates Kv7.1 cell surface expression. , Andersen MN., Traffic. January 1, 2012; 13 (1): 143-56.
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone- SGK1- Nedd4-2 pathway. , Arroyo JP., J Am Soc Nephrol. September 1, 2011; 22 (9): 1707-19.
AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. , Alzamora R., Am J Physiol Renal Physiol. December 1, 2010; 299 (6): F1308-19.
COMMD1 downregulates the epithelial sodium channel through Nedd4-2. , Ke Y., Am J Physiol Renal Physiol. June 1, 2010; 298 (6): F1445-56.
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. , Edinger RS., J Biol Chem. January 2, 2009; 284 (1): 150-157.
A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus. , Jean S., Differentiation. April 1, 2008; 76 (4): 431-41.
Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation. , Fakitsas P., J Am Soc Nephrol. April 1, 2007; 18 (4): 1084-92.
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase ( Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. , Rauh R., Pflugers Arch. June 1, 2006; 452 (3): 290-9.
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells. , Flores SY., J Am Soc Nephrol. August 1, 2005; 16 (8): 2279-87.
Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits. , Malik B., Am J Physiol Renal Physiol. July 1, 2005; 289 (1): F107-16.
Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. , Hryciw DH., J Biol Chem. December 31, 2004; 279 (53): 54996-5007.
Regulation of CLC-Ka/ barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. , Embark HM., Kidney Int. November 1, 2004; 66 (5): 1918-25.
Differential expression and localisation of WWP1, a Nedd4-like protein, in epithelia. , Malbert-Colas L., Pflugers Arch. October 1, 2003; 447 (1): 35-43.
SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells. , Verrey F., Cell Physiol Biochem. January 1, 2003; 13 (1): 21-8.
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. , Shigaev A., Am J Physiol Renal Physiol. April 1, 2000; 278 (4): F613-9.
Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. , Farr TJ., Biochem J. February 1, 2000; 345 Pt 3 503-9.
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. , Abriel H., J Clin Invest. March 1, 1999; 103 (5): 667-73.
Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. , Goulet CC., J Biol Chem. November 6, 1998; 273 (45): 30012-7.
Molecular cloning of Nedd4 from Xenopus laevis. , Rebhun JF., DNA Seq. January 1, 1998; 9 (5-6): 295-306.