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Summary Expression Phenotypes Gene Literature (93) GO Terms (4) Nucleotides (72) Proteins (41) Interactants (83) Wiki
XB-GENEPAGE-6048234

Papers associated with kcnj12



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Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways., Seldeslachts A, Peigneur S, Tytgat J., Membranes (Basel). December 2, 2023; 13 (12):               

WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels., An D, Peigneur S, Tytgat J., Biomedicines. April 28, 2021; 9 (5):               

Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               

Identification of a unique endoplasmic retention motif in the Xenopus GIRK5 channel and its contribution to oocyte maturation., Rangel-Garcia CI, Salvador C, Chavez-Garcia K, Diaz-Bello B, Lopez-Gonzalez Z, Vazquez-Cruz L, Angel Vazquez-Martinez J, Ortiz-Navarrete V, Riveros-Rosas H, Escobar LI., FEBS Open Bio. April 1, 2021; 11 (4): 1093-1108.            

Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels., Wiedmann F, Schlund D, Kraft M, Nietfeld J, Katus HA, Schmidt C, Thomas D., Europace. September 1, 2020; 22 (9): 1409-1418.

Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference., Koepple C, Scherer D, Seyler C, Scholz E, Thomas D, Katus HA, Zitron E., J Pharmacol Exp Ther. May 1, 2017; 361 (2): 209-218.

P639Amiodarone and dronedarone inhibit inwardly rectifying Kir2.1 channels, but not Kir2.2 and Kir2.3 channels., Seyler C, Xynogalos P, Scherer D, Koepple C, Scholz E, Thomas D, Katus H, Zitron E., Cardiovasc Res. July 15, 2014; 103 Suppl 1 S116.

Novel TASK channels inhibitors derived from dihydropyrrolo[2,1-a]isoquinoline., Noriega-Navarro R, Lopez-Charcas O, Hernández-Enríquez B, Reyes-Gutiérrez PE, Martínez R, Landa A, Morán J, Gomora JC, Garcia-Valdes J., Neuropharmacology. April 1, 2014; 79 28-36.

Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+., Li J, Xie X, Liu J, Yu H, Zhang S, Zhan Y, Zhang H, Logothetis DE, An H., PLoS One. January 1, 2014; 9 (10): e111372.              

Identification of compound heterozygous KCNJ1 mutations (encoding ROMK) in a kindred with Bartter's syndrome and a functional analysis of their pathogenicity., Srivastava S, Li D, Edwards N, Hynes AM, Wood K, Al-Hamed M, Wroe AC, Reaich D, Moochhala SH, Welling PA, Sayer JA., Physiol Rep. November 1, 2013; 1 (6): e00160.          

Non dominant-negative KCNJ2 gene mutations leading to Andersen-Tawil syndrome with an isolated cardiac phenotype., Limberg MM, Zumhagen S, Netter MF, Coffey AJ, Grace A, Rogers J, Böckelmann D, Rinné S, Stallmeyer B, Decher N, Schulze-Bahr E., Basic Res Cardiol. May 1, 2013; 108 (3): 353.

IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway., Emtage L, Aziz-Zaman S, Padovan-Merhar O, Horvitz HR, Fang-Yen C, Ringstad N., J Neurosci. November 14, 2012; 32 (46): 16285-95.

Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A., Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.

Identification of selective agonists and antagonists to g protein-activated inwardly rectifying potassium channels: candidate medicines for drug dependence and pain., Nishizawa D, Gajya N, Ikeda K., Curr Neuropharmacol. March 1, 2011; 9 (1): 113-7.      

Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution., Tao X, Avalos JL, Chen J, MacKinnon R., Science. December 18, 2009; 326 (5960): 1668-74.

Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3., Kobayashi T, Washiyama K, Ikeda K., PLoS One. July 21, 2009; 4 (7): e6311.              

Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors., Zitron E, Günth M, Scherer D, Kiesecker C, Kulzer M, Bloehs R, Scholz EP, Thomas D, Weidenhammer C, Kathöfer S, Bauer A, Katus HA, Karle CA., J Mol Cell Cardiol. January 1, 2008; 44 (1): 84-94.

Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2., Scherer D, Kiesecker C, Kulzer M, Günth M, Scholz EP, Kathöfer S, Thomas D, Maurer M, Kreuzer J, Bauer A, Katus HA, Karle CA, Zitron E., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2007; 375 (5): 311-22.

Evidence for sequential ion-binding loci along the inner pore of the IRK1 inward-rectifier K+ channel., Shin HG, Xu Y, Xu Y, Lu Z., J Gen Physiol. August 1, 2005; 126 (2): 123-35.                            

Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine., Shin HG, Lu Z., J Gen Physiol. April 1, 2005; 125 (4): 413-26.                      

Characterization of inward-rectifier K+ channel inhibition by antiarrhythmic piperazine., Xu Y, Xu Y, Lu Z., Biochemistry. December 14, 2004; 43 (49): 15577-83.

betaL-betaM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(betagamma) subunit activation., Finley M, Arrabit C, Fowler C, Suen KF, Slesinger PA., J Physiol. March 16, 2004; 555 (Pt 3): 643-57.

Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction., Zhang L, Lee JK, Lee JK, John SA, Uozumi N, Kodama I., J Biol Chem. February 20, 2004; 279 (8): 7037-47.

Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels., Guo D, Lu Z., J Gen Physiol. November 1, 2003; 122 (5): 485-500.                                    

Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes., Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K., FEBS Lett. November 6, 2002; 531 (2): 250-4.

IRK1 inward rectifier K(+) channels exhibit no intrinsic rectification., Guo D, Lu Z., J Gen Physiol. October 1, 2002; 120 (4): 539-51.                            

Inhibition of cardiac potassium currents by pentobarbital., Bachmann A, Mueller S, Kopp K, Brueggemann A, Suessbrich H, Gerlach U, Busch AE., Naunyn Schmiedebergs Arch Pharmacol. January 1, 2002; 365 (1): 29-37.

Unitary conductance variation in Kir2.1 and in cardiac inward rectifier potassium channels., Picones A, Keung E, Timpe LC., Biophys J. October 1, 2001; 81 (4): 2035-49.

Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues., Alagem N, Dvir M, Reuveny E., J Physiol. July 15, 2001; 534 (Pt. 2): 381-93.

Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels., Yamakura T, Lewohl JM, Harris RA., Anesthesiology. July 1, 2001; 95 (1): 144-53.

Identification of G protein-coupled, inward rectifier potassium channel gene products from the rat anterior pituitary gland., Gregerson KA, Flagg TP, O'Neill TJ, Anderson M, Lauring O, Horel JS, Welling PA., Endocrinology. July 1, 2001; 142 (7): 2820-32.

Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels., Zhou W, Arrabit C, Choe S, Slesinger PA., Proc Natl Acad Sci U S A. May 22, 2001; 98 (11): 6482-7.

Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel., Kubo Y, Murata Y., J Physiol. March 15, 2001; 531 (Pt 3): 645-60.

Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels., Slesinger PA., Biophys J. February 1, 2001; 80 (2): 707-18.

Single channel studies of inward rectifier potassium channel regulation by muscarinic acetylcholine receptors., Bard J, Kunkel MT, Peralta EG., J Gen Physiol. November 1, 2000; 116 (5): 645-52.          

Pore block versus intrinsic gating in the mechanism of inward rectification in strongly rectifying IRK1 channels., Guo D, Lu Z., J Gen Physiol. October 1, 2000; 116 (4): 561-8.              

Cs+ block of the cardiac muscarinic K+ channel, GIRK1/GIRK4, is not dependent on the aspartate residue at position 173., Dibb KM, Leach R, Lancaster MK, Findlay JB, Boyett MR., Pflugers Arch. September 1, 2000; 440 (5): 740-4.

Molecular cloning and expression of an inwardly rectifying K(+) channel from bovine corneal endothelial cells., Yang D, Sun F, Thomas LL, Offord J, MacCallum DK, Dawson DC, Hughes BA, Ernst SA., Invest Ophthalmol Vis Sci. September 1, 2000; 41 (10): 2936-44.

Expression cloning of KCRF, a potassium channel regulatory factor., Keren-Raifman T, Ivanina T, Bismuth Y, Dascal N., Biochem Biophys Res Commun. August 11, 2000; 274 (3): 852-8.

Mechanism of IRK1 channel block by intracellular polyamines., Guo D, Lu Z., J Gen Physiol. June 1, 2000; 115 (6): 799-814.                          

Direct block of inward rectifier potassium channels by nicotine., Wang H, Yang B, Zhang L, Xu D, Wang Z., Toxicol Appl Pharmacol. April 1, 2000; 164 (1): 97-101.

Permeation properties of inward-rectifier potassium channels and their molecular determinants., Choe H, Sackin H, Palmer LG., J Gen Physiol. April 1, 2000; 115 (4): 391-404.                      

[Blocking effects of extracellular Ba(2+) on the inward rectifier potassium channel], Xie A, Zang YM., Sheng Li Xue Bao. February 1, 2000; 52 (1): 50-4.

Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides., Rohács T, Chen J, Prestwich GD, Logothetis DE., J Biol Chem. December 17, 1999; 274 (51): 36065-72.

The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands., Ulens C, Daenens P, Tytgat J., Eur J Pharmacol. December 3, 1999; 385 (2-3): 239-45.

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action., Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA, Harris RA., Nat Neurosci. December 1, 1999; 2 (12): 1084-90.

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions., Zhang H, He C, Yan X, Mirshahi T, Logothetis DE., Nat Cell Biol. July 1, 1999; 1 (3): 183-8.

Structural determinants of gating in inward-rectifier K+ channels., Choe H, Palmer LG, Sackin H., Biophys J. April 1, 1999; 76 (4): 1988-2003.

Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells., Bradley KK, Jaggar JH, Bonev AD, Heppner TJ, Flynn ER, Nelson MT, Horowitz B., J Physiol. March 15, 1999; 515 ( Pt 3) 639-51.

Nonindependent K+ movement through the pore in IRK1 potassium channels., Stampe P, Arreola J, Pérez-Cornejo P, Begenisich T., J Gen Physiol. October 1, 1998; 112 (4): 475-84.          

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