| Monarch Ortholog Phenotypes
|
Human (27 sources):
Abnormal bleeding,
Abnormality of coagulation,
Abnormality of the coagulation cascade,
Acholic stools,
Biliary tract abnormality,
Cirrhosis,
Diarrhea,
Elevated circulating hepatic transaminase concentration,
Failure to thrive,
Fat malabsorption,
Gastrointestinal hemorrhage,
Giant cell hepatitis,
Hepatic failure,
Hepatomegaly,
Hyperbilirubinemia,
Hypocholesterolemia,
Intrahepatic cholestasis,
Jaundice,
Malabsorption,
Neonatal cholestatic liver disease,
Nyctalopia,
Osteoporosis,
Peripheral neuropathy,
Pruritus,
Rickets,
Splenomegaly,
Steatorrhea
[+]
|
|
Mouse (6 sources):
abnormal bile salt homeostasis,
decreased intestinal cholesterol absorption,
increased fatty acids level,
increased liver triglyceride level,
oily skin,
postnatal lethality, complete penetrance
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.