Monarch Ortholog Phenotypes
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Human (87 sources):
2-3 toe syndactyly,
Abnormal periventricular white matter morphology,
Abnormality of the dentition,
Abnormality of the kidney,
Accelerated skeletal maturation,
Agenesis of corpus callosum,
Aggressive behavior,
Arachnoid cyst,
Autism,
Autistic behavior,
Behavioral abnormality,
Broad-based gait,
Bruxism,
Bulbous nose,
Cellulitis,
Cerebellar cortical atrophy,
Cerebral visual impairment,
Clinodactyly of the 5th finger,
Concave nasal ridge,
Deeply set eye,
Delayed CNS myelination,
Delayed speech and language development,
Dental crowding,
Dental malocclusion,
Dolichocephaly,
Epicanthus,
Episodic vomiting,
Feeding difficulties,
Full cheeks,
Gastroesophageal reflux,
Generalized hypotonia,
Global developmental delay,
Hair-pulling,
Hearing impairment,
Heat intolerance,
High palate,
Hydronephrosis,
Hyperactivity,
Hypermetropia,
Hyperorality,
Hypohidrosis,
Hypoplastic toenails,
Hyporeflexia,
Immunodeficiency,
Impaired pain sensation,
Intellectual disability,
Intellectual disability, moderate,
Large hands,
Long eyelashes,
Long philtrum,
Lymphedema,
Macrocephaly,
Macrotia,
Malar flattening,
Microcephaly,
Motor delay,
Motor stereotypy,
Nausea and vomiting,
Neonatal hypotonia,
Obesity,
Palpebral edema,
Patent ductus arteriosus,
Pointed chin,
Polycystic kidney dysplasia,
Poor eye contact,
Prominent supraorbital ridges,
Protruding ear,
Ptosis,
Recurrent pyelonephritis,
Recurrent skin infections,
Renal dysplasia,
Sacral dimple,
Seizure,
Short chin,
Sleep disturbance,
Strabismus,
Tall stature,
Thick eyebrow,
Toenail dysplasia,
Tongue thrusting,
Umbilical hernia,
Unsteady gait,
Ventricular septal defect,
Ventriculomegaly,
Vesicoureteral reflux,
Wide nasal bridge,
obsolete Impaired social interactions
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Mouse (101 sources):
abnormal CNS synaptic transmission,
abnormal allogrooming behavior,
abnormal basal ganglion morphology,
abnormal brain commissure morphology,
abnormal brain internal capsule morphology,
abnormal brain wave pattern,
abnormal brain white matter morphology,
abnormal cerebellar peduncle morphology,
abnormal cingulum morphology,
abnormal conditioned emotional response,
abnormal dendritic spine morphology,
abnormal ear development,
abnormal excitatory postsynaptic currents,
abnormal excitatory postsynaptic potential,
abnormal glutamate-mediated receptor currents,
abnormal habituation to a novel odor,
abnormal impulsive behavior control,
abnormal innate avoidance response,
abnormal learning/memory/conditioning,
abnormal locomotor activation,
abnormal long term depression,
abnormal long term object recognition memory,
abnormal medium spiny neuron morphology,
abnormal miniature excitatory postsynaptic currents,
abnormal miniature inhibitory postsynaptic currents,
abnormal motor capabilities/coordination/movement,
abnormal motor learning,
abnormal nest building behavior,
abnormal neuron physiology,
abnormal object recognition memory,
abnormal odor adaptation,
abnormal paired-pulse inhibition,
abnormal postsynaptic density morphology,
abnormal response to new environment,
abnormal response to novel object,
abnormal response to novelty,
abnormal response to social novelty,
abnormal righting response,
abnormal sexual interaction,
abnormal single cell response,
abnormal social investigation,
abnormal social recognition,
abnormal spatial learning,
abnormal spatial reference memory,
abnormal spinal cord commissure morphology,
abnormal startle reflex,
abnormal synapse morphology,
abnormal vocalization,
behavior/neurological phenotype,
circling,
decreased amygdala size,
decreased anxiety-related response,
decreased excitatory postsynaptic current amplitude,
decreased exploration in new environment,
decreased grip strength,
decreased locomotor activity,
decreased post-tetanic potentiation,
decreased prepulse inhibition,
decreased startle reflex,
decreased stereotypic behavior,
decreased susceptibility to pharmacologically induced seizures,
decreased synaptic depression,
decreased thermal nociceptive threshold,
decreased vertical activity,
decreased vocalization,
enhanced contextual conditioning behavior,
enhanced cued conditioning behavior,
environmentally induced seizures,
excessive vocalization,
growth/size/body region phenotype,
hyporesponsive to tactile stimuli,
impaired contextual conditioning behavior,
impaired discrimination learning,
impaired learning,
impaired righting response,
impaired spatial learning,
impaired synaptic plasticity,
increased aggression towards mice,
increased anxiety-related response,
increased fear-related response,
increased grooming behavior,
increased startle reflex,
increased thigmotaxis,
increased vertical activity,
induced hyperactivity,
integument phenotype,
lethality, incomplete penetrance,
long stride length,
neonatal lethality, incomplete penetrance,
nervous system phenotype,
premature death,
premature suckling reflex loss,
reduced NMDA-mediated synaptic currents,
reduced long term depression,
reduced long term potentiation,
skin lesions,
small hippocampus,
social withdrawal,
taste/olfaction phenotype,
thalamus hyperplasia,
weakness
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View all ortholog results at Monarch
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