Monarch Ortholog Phenotypes
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Human (37 sources):
Broad forehead,
Broad nasal tip,
Clinodactyly of the 5th finger,
Depressed nasal bridge,
Depressed nasal ridge,
Distal/middle symphalangism of 5th finger,
Downslanted palpebral fissures,
Everted lower lip vermilion,
Global developmental delay,
Hand polydactyly,
Hearing impairment,
Highly arched eyebrow,
Hypertelorism,
Intellectual disability, mild,
Low-set ears,
Malar flattening,
Mesoaxial foot polydactyly,
Mesoaxial hand polydactyly,
Myopia,
Parasomnia,
Patent ductus arteriosus,
Persistence of primary teeth,
Prominent occiput,
Protruding ear,
Ptosis,
Short middle phalanx of the 5th finger,
Short philtrum,
Sleep disturbance,
Strabismus,
Supernumerary nipple,
Symphalangism of the 5th finger,
Thick eyebrow,
Thick vermilion border,
Toe syndactyly,
Triangular mouth,
Ventricular septal defect,
obsolete No permanent dentition
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Mouse (36 sources):
abnormal corneal stroma morphology,
abnormal fetal ductus arteriosus morphology,
abnormal iridocorneal angle,
abnormal kidney morphology,
abnormal lens epithelium morphology,
abnormal pulmonary alveolar system morphology,
abnormal vascular smooth muscle physiology,
absent corneal endothelium,
craniofacial phenotype,
decreased amacrine cell number,
decreased corneal epithelium thickness,
decreased total retina thickness,
decreased urine osmolality,
dilated proximal convoluted tubule,
dilated renal tubules,
eye opacity,
fused cornea and lens,
increased cardiac muscle contractility,
increased circulating creatinine level,
increased circulating parathyroid hormone level,
increased grip strength,
increased kidney apoptosis,
increased renal tubule apoptosis,
kidney vascular congestion,
limbs/digits/tail phenotype,
neonatal lethality, complete penetrance,
neonatal lethality, incomplete penetrance,
ocular hypertension,
optic nerve cupping,
optic nerve degeneration,
postnatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
pulmonary vascular congestion,
retina ganglion cell degeneration,
small kidney,
thin retina inner plexiform layer
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View all ortholog results at Monarch
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