cd274 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-921386

Gene Symbol: cd274 Gene Name: CD274 molecule

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: cd274 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (36 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha-beta T cell physiology, abnormal T follicular helper cell physiology, abnormal T-helper 1 cell differentiation, abnormal dendritic cell physiology, abnormal regulatory T cell physiology, decreased IgG1 level, decreased IgG2a level, decreased T cell apoptosis, decreased T helper 1 cell number, decreased T-helper 17 cell number, decreased germinal center B cell number, decreased interleukin-17 secretion, decreased plasma cell number, decreased susceptibility to Riboviria infection, decreased susceptibility to Riboviria infection induced morbidity/mortality, decreased susceptibility to parasitic infection, hematopoietic system phenotype, hyperresponsive to tactile stimuli, immune system phenotype, increased CD8-positive, alpha-beta T cell number, increased IgG1 level, increased IgG2c level, increased T cell proliferation, increased activated T cell number, increased interferon-gamma secretion, increased interleukin-4 secretion, increased susceptibility to autoimmune diabetes, increased susceptibility to autoimmune disorder, increased susceptibility to bacterial infection induced morbidity/mortality, increased susceptibility to experimental autoimmune encephalomyelitis, increased susceptibility to induced arthritis, increased susceptibility to injury, increased tumor necrosis factor secretion, lethality throughout fetal growth and development, incomplete penetrance [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (36 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha-beta T cell physiology, abnormal T follicular helper cell physiology, abnormal T-helper 1 cell differentiation, abnormal dendritic cell physiology, abnormal regulatory T cell physiology, decreased IgG1 level, decreased IgG2a level, decreased T cell apoptosis, [+]