Monarch Ortholog Phenotypes
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Human (1 source):
Hyperkeratosis
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Mouse (40 sources):
abnormal T cell differentiation,
abnormal bone marrow morphology,
abnormal definitive hematopoiesis,
abnormal embryonic neuroepithelial layer differentiation,
abnormal embryonic/fetal subventricular zone morphology,
abnormal forebrain development,
abnormal granulocyte differentiation,
abnormal paraxial mesoderm morphology,
abnormal pontine flexure morphology,
abnormal somite development,
abnormal umbilical cord morphology,
abnormal visceral yolk sac morphology,
abnormal vitelline vasculature morphology,
absent intersomitic vessels,
absent marginal zone B cells,
decreased CD4-positive, alpha beta T cell number,
decreased double-positive T cell number,
decreased embryo size,
decreased erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased transitional stage T2 B cell number,
delayed heart development,
digestive/alimentary phenotype,
distended pericardium,
embryonic lethality during organogenesis, complete penetrance,
failure of vascular branching,
forestomach hypoplasia,
increased follicular B cell number,
increased hematopoietic stem cell number,
increased neutrophil cell number,
increased spleen red pulp amount,
increased spleen weight,
increased transitional stage T1 B cell number,
myeloid hyperplasia,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
small first pharyngeal arch,
small thymus,
spleen hyperplasia
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View all ortholog results at Monarch
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