Monarch Ortholog Phenotypes
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Human (60 sources):
Abnormal lower motor neuron morphology,
Abnormal pyramidal sign,
Abnormal upper motor neuron morphology,
Amyotrophic lateral sclerosis,
Areflexia,
Ataxia,
Axonal degeneration,
Babinski sign,
Cerebellar atrophy,
Cerebellar vermis atrophy,
Chorea,
Choreoathetosis,
Chronic axonal neuropathy,
Clonus,
Conjunctival telangiectasia,
Decreased motor nerve conduction velocity,
Degeneration of anterior horn cells,
Difficulty walking,
Diffuse axonal swelling,
Distal amyotrophy,
Distal muscle weakness,
Dysarthria,
Dysphagia,
Dystonia,
Elevated alpha-fetoprotein,
Elevated circulating creatine kinase concentration,
Gait ataxia,
Gait disturbance,
Gait imbalance,
Gaze-evoked nystagmus,
Head tremor,
Hypercholesterolemia,
Hyperreflexia,
Hypoalbuminemia,
Hyporeflexia,
Impaired distal tactile sensation,
Impaired distal vibration sensation,
Impaired proprioception,
Increased circulating antibody level,
Limb ataxia,
Nystagmus,
Oculomotor apraxia,
Pallor of dorsal columns of the spinal cord,
Peripheral axonal degeneration,
Peripheral axonal neuropathy,
Pes cavus,
Polyneuropathy,
Pontocerebellar atrophy,
Postural tremor,
Progressive gait ataxia,
Reduced tendon reflexes,
Saccadic smooth pursuit,
Scoliosis,
Sensorimotor neuropathy,
Skeletal muscle atrophy,
Somatic sensory dysfunction,
Spastic paraplegia,
Strabismus,
Tremor,
Urinary bladder sphincter dysfunction
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Mouse (17 sources):
abnormal double-strand DNA break repair,
abnormal male germ cell apoptosis,
abnormal male meiosis,
abnormal seminiferous tubule epithelium morphology,
abnormal seminiferous tubule morphology,
abnormal spermiogenesis,
abnormal total retina thickness,
arrest of male meiosis,
decreased grip strength,
decreased total retina thickness,
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View all ortholog results at Monarch
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