| Monarch Ortholog Phenotypes
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Human (16 sources):
Anemia,
Cholelithiasis,
Exercise intolerance,
Exercise-induced muscle cramps,
Exercise-induced myoglobinuria,
Gout,
Hemolytic anemia,
Hyperuricemia,
Increased muscle glycogen content,
Increased total bilirubin,
[+]
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Mouse (20 sources):
abnormal angiogenesis,
abnormal muscle regeneration,
cardiac hypertrophy,
decreased circulating lactate level,
decreased hematocrit,
decreased insulin secretion,
hypoxia,
impaired exercise endurance,
increased cardiac muscle glycogen level,
increased circulating glucose level,
increased erythrocyte osmotic fragility,
increased heart weight,
increased hematopoietic stem cell number,
increased lactate dehydrogenase level,
increased skeletal muscle glycogen level,
increased spleen weight,
lethality at weaning, incomplete penetrance,
premature death,
skeletal muscle fiber degeneration,
skeletal muscle fiber necrosis
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.