pik3cg Phenotypes

Phenotypes

XB-GENEPAGE-1011008

Gene Symbol: pik3cg Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (35 sources): abnormal CD8-positive, alpha-beta T cell physiology, abnormal NK cell differentiation, abnormal T cell activation, abnormal T cell differentiation, abnormal T-helper 2 physiology, abnormal cardiac muscle relaxation, abnormal definitive hematopoiesis, abnormal immune cell physiology, abnormal leukocyte physiology, abnormal macrophage physiology, abnormal myocardial fiber morphology, abnormal response to infection, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, decreased circulating alanine transaminase level, decreased circulating aspartate transaminase level, decreased cytotoxic T cell cytolysis, decreased interferon-gamma secretion, decreased interleukin-2 secretion, decreased macrophage cell number, decreased platelet calcium level, decreased susceptibility to induced arthritis, decreased susceptibility to induced thrombosis, decreased thymocyte number, immune system phenotype, impaired macrophage chemotaxis, impaired neutrophil recruitment, increased cardiac muscle contractility, increased interleukin-1 beta secretion, increased interleukin-6 secretion, increased neutrophil cell number, increased sensitivity to induced morbidity/mortality, increased susceptibility to Poxviridae infection, increased tumor necrosis factor secretion, skin lesions [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (35 sources): abnormal CD8-positive, alpha-beta T cell physiology, abnormal NK cell differentiation, abnormal T cell activation, abnormal T cell differentiation, abnormal T-helper 2 physiology, abnormal cardiac muscle relaxation, abnormal definitive hematopoiesis, abnormal immune cell physiology, abnormal leukocyte physiology, abnormal macrophage physiology, [+]