Bradycardia, Bulbous nose, Congenital diaphragmatic hernia, Congestive heart failure, Convex nasal ridge, Cutis laxa, Delayed cranial suture closure, Depressed nasal bridge, Downslanted palpebral fissures, Emphysema, Full cheeks, Generalized arterial tortuosity, Generalized hypotonia, Hernia, High palate, Hypertelorism, Hypothyroidism, Hypotonia, Ileus, Joint hypermobility, Low-set ears, Microcephaly, Micrognathia, Narrow palpebral fissure, Oligohydramnios, Osteoporosis, Overgrowth, Pectus excavatum, Premature skin wrinkling, Prematurely aged appearance, Prominence of the premaxilla, Prominent forehead, Proptosis, Ptosis, Pulmonary artery aneurysm, Pulmonary artery dilatation, Pulmonary insufficiency, Pulmonic stenosis, Recurrent fractures, Recurrent urinary tract infections, Redundant skin, Renal diverticulum, Respiratory distress, Soft skin, Vascular dilatation, Vesicoureteral reflux, Wormian bones, obsolete Joint hyperflexibility

abnormal cutaneous collagen fibril morphology, abnormal cutaneous elastic fiber morphology, abnormal descending aorta morphology, abnormal forelimb morphology, abnormal hypodermis morphology, abnormal hypodermis muscle layer morphology, abnormal pulmonary elastic fiber morphology, abnormal tendon collagen fibril morphology, abnormal vascular smooth muscle morphology, abnormal vascular smooth muscle physiology, ascending aorta aneurysm, decreased systemic arterial diastolic blood pressure, descending aorta stenosis, embryonic lethality during organogenesis, complete penetrance, focal dorsal hair loss, increased aorta wall thickness, increased pulse pressure, increased vascular endothelial cell apoptosis, increased vascular endothelial cell proliferation, neonatal lethality, complete penetrance, no abnormal phenotype detected, overexpanded pulmonary alveoli, perinatal lethality, complete penetrance, premature death, thin dermal layer, vascular smooth muscle hyperplasia, wheezing