smpd3 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-1013641

Gene Symbol: smpd3 Gene Name: sphingomyelin phosphodiesterase 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: smpd3 assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (44 sources): abnormal adenohypophysis morphology, abnormal alveolar process morphology, abnormal bone mineralization, abnormal cartilage development, abnormal clavicle morphology, abnormal dentin development, abnormal epiphyseal plate morphology, abnormal humerus morphology, abnormal ischium morphology, abnormal limb morphology, abnormal lipid level, abnormal long bone metaphysis morphology, abnormal olecranon morphology, abnormal osteoblast morphology, abnormal ovarian follicle morphology, abnormal ovary development, abnormal perichondrium morphology, abnormal pituicyte morphology, abnormal pubis morphology, abnormal pulmonary alveolus morphology, abnormal sternum ossification, abnormal testis development, decreased body length, decreased body size, decreased bone trabecula number, decreased circulating insulin-like growth factor I level, decreased corticotroph cell number, decreased gonadotroph cell number, decreased somatotroph cell number, decreased survivor rate, decreased thyrotroph cell number, decreased thyroxine level, decreased triiodothyronine level, decreased width of hypertrophic chondrocyte zone, delayed bone ossification, disproportionate dwarf, fetal growth retardation, increased circulating parathyroid hormone level, increased lung compliance, increased width of hypertrophic chondrocyte zone, overexpanded pulmonary alveoli, postnatal lethality, incomplete penetrance, reduced fertility, rib fractures [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (44 sources): abnormal adenohypophysis morphology, abnormal alveolar process morphology, abnormal bone mineralization, abnormal cartilage development, abnormal clavicle morphology, abnormal dentin development, abnormal epiphyseal plate morphology, abnormal humerus morphology, abnormal ischium morphology, abnormal limb morphology, [+]