irs1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-478671

Gene Symbol: irs1 Gene Name: insulin receptor substrate 1

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (45 sources): abnormal bone healing, abnormal bone mineralization, abnormal cell differentiation, abnormal lipid level, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone hypertrophic chondrocyte zone, abnormal osteoblast physiology, abnormal osteoclast differentiation, abnormal osteoclast physiology, abnormal pancreatic beta cell morphology, abnormal postnatal growth/weight/body size, abnormal tail morphology, abnormal vascular wound healing, decreased birth weight, decreased body length, decreased body size, decreased bone mineral content, decreased cell proliferation, decreased chondrocyte number, decreased circulating glucose level, decreased fetal weight, decreased insulin secretion, decreased long bone epiphyseal plate size, decreased osteoblast cell number, decreased osteoblast proliferation, decreased percent body fat/body weight, decreased trabecular bone thickness, decreased vasodilation, fetal growth retardation, homeostasis/metabolism phenotype, impaired lipolysis, impaired osteoblast differentiation, increased or absent threshold for auditory brainstem response, increased osteoblast cell number, increased osteoclast cell number, increased systemic arterial diastolic blood pressure, increased systemic arterial systolic blood pressure, postnatal lethality, premature death, preweaning lethality, complete penetrance, proportional dwarf, short tail, skeleton phenotype, thin tail, vision/eye phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (45 sources): abnormal bone healing, abnormal bone mineralization, abnormal cell differentiation, abnormal lipid level, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone hypertrophic chondrocyte zone, abnormal osteoblast physiology, abnormal osteoclast differentiation, abnormal osteoclast physiology, abnormal pancreatic beta cell morphology, [+]