| Monarch Ortholog Phenotypes
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Human (20 sources):
Abnormal cardiac septum morphology,
Abnormal localization of kidney,
Abnormal nasal morphology,
Absent speech,
Depressed nasal bridge,
Global developmental delay,
High forehead,
Hydrocephalus,
Hypertelorism,
Macrocephaly,
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Mouse (31 sources):
abnormal Purkinje cell dendrite morphology,
abnormal Purkinje cell morphology,
abnormal adipose tissue amount,
abnormal cerebellar foliation,
abnormal cerebellar granule layer morphology,
abnormal cerebellar molecular layer,
abnormal cerebellum external granule cell layer morphology,
abnormal cranium morphology,
abnormal grip strength,
abnormal lean body mass,
abnormal mean corpuscular volume,
abnormal myocardial fiber physiology,
abnormal ovarian folliculogenesis,
abnormal ovulation,
abnormal response to cardiac infarction,
abnormal spine curvature,
abnormal spleen weight,
decreased bone mineral content,
decreased myocardial infarct size,
decreased spleen weight,
decreased testis weight,
increased bone mineral content,
increased circulating alkaline phosphatase level,
increased circulating iron level,
increased fasting circulating glucose level,
increased grip strength,
increased heart weight,
increased lean body mass,
small cerebellum,
thin external granule cell layer,
trunk curl
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.