| Monarch Ortholog Phenotypes
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Human (42 sources):
Abnormality of neutrophils,
Absence of bactericidal oxidative respiratory burst in phagocytes,
Cellulitis,
Chronic pulmonary obstruction,
Cutaneous photosensitivity,
Decreased activity of NADPH oxidase,
Discoid lupus rash,
Eczematoid dermatitis,
Fever,
Gingivitis,
Granulomatosis,
Hepatomegaly,
Hypermelanotic macule,
Immunodeficiency,
Impaired oxidative burst,
Inflammatory abnormality of the eye,
Liver abscess,
Lymphadenitis,
Lymphadenopathy,
Macule,
Malabsorption,
Mediastinal lymphadenopathy,
Meningitis,
Osteomyelitis,
Otitis media,
Pyloric stenosis,
Rectal abscess,
Recurrent Aspergillus infections,
Recurrent Burkholderia cepacia infections,
Recurrent E. coli infections,
Recurrent Klebsiella infections,
Recurrent Serratia marcescens infections,
Recurrent Staphylococcus aureus infections,
Recurrent bacterial skin infections,
Recurrent pneumonia,
Recurrent respiratory infections,
Sepsis,
Sinusitis,
Skin ulcer,
Splenomegaly,
Tracheoesophageal fistula,
obsolete Eczematoid dermatitis
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Mouse (25 sources):
abnormal circulating alkaline phosphatase level,
abnormal kidney interstitium morphology,
abnormal mesangial matrix morphology,
abnormal redox activity,
abnormal renal glomerulus morphology,
abnormal spleen germinal center morphology,
decreased NK T cell number,
decreased alpha-beta T cell number,
decreased grip strength,
decreased regulatory T cell number,
glomerular crescent,
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased CD4-positive, alpha-beta memory T cell number,
increased CD8-positive, alpha-beta T cell number,
increased KLRG1-positive NK cell number,
increased activated T cell number,
increased anti-double stranded DNA antibody level,
increased circulating alkaline phosphatase level,
increased follicular B cell number,
increased germinal center B cell number,
increased susceptibility to fungal infection,
increased susceptibility to systemic lupus erythematosus,
premature death,
renal glomerular immunoglobulin deposits,
renal glomerular protein deposits
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.