| Monarch Ortholog Phenotypes
|
Human (30 sources):
Abnormality of the liver,
Anal atresia,
Arthralgia,
Autoimmune thrombocytopenia,
Brachycephaly,
Bronchiectasis,
Chronic otitis media,
Conjunctivitis,
Decreased circulating antibody level,
Elevated circulating hepatic transaminase concentration,
Emphysema,
Failure to thrive in infancy,
Gastrointestinal stroma tumor,
Hemolytic anemia,
Immunodeficiency,
Lymphadenopathy,
Lymphoma,
Lymphopenia,
Otitis media,
Pneumonia,
Posterior pharyngeal cleft,
Purpura,
Recurrent bacterial infections,
Recurrent bronchitis,
Recurrent otitis media,
Recurrent respiratory infections,
Recurrent sinusitis,
Restrictive ventilatory defect,
Splenomegaly,
Vasculitis
[+]
|
Mouse (29 sources):
abnormal circulating phosphate level,
abnormal humoral immune response,
abnormal vitreous body morphology,
absent spleen germinal center,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased IgG1 level,
decreased IgG2a level,
decreased IgG2b level,
decreased IgG3 level,
decreased anti-double stranded DNA antibody level,
decreased anti-nuclear antigen antibody level,
decreased circulating interferon-gamma level,
decreased circulating interleukin-10 level,
decreased circulating interleukin-4 level,
decreased circulating interleukin-6 level,
decreased circulating tumor necrosis factor level,
decreased interleukin-10 secretion,
decreased physiological sensitivity to xenobiotic,
decreased tumor necrosis factor secretion,
increased CD8-positive, alpha-beta T cell number,
increased interferon-gamma secretion,
increased neutrophil cell number,
increased sensitivity to induced morbidity/mortality,
increased susceptibility to experimental autoimmune encephalomyelitis,
increased susceptibility to injury,
no abnormal phenotype detected,
skin fibrosis,
thick dermal layer
[+]
|
View all ortholog results at Monarch
|
These phenotypes are associated with this gene with a has phenotype relation via Monarch.