| Monarch Ortholog Phenotypes
|
Human (27 sources):
Aggressive behavior,
Akinesia,
Ataxia,
Cerebellar atrophy,
Depression,
Difficulty walking,
Dysarthria,
Dysgraphia,
Dysmetric saccades,
Gait ataxia,
Gait disturbance,
Gaze-evoked nystagmus,
Hand tremor,
Head tremor,
Impaired smooth pursuit,
Impaired vibratory sensation,
Intellectual disability, mild,
Limb ataxia,
Memory impairment,
Orofacial dyskinesia,
Pes cavus,
Postural tremor,
Red-green dyschromatopsia,
Sensory axonal neuropathy,
Strabismus,
Tremor,
Truncal ataxia
[+]
|
|
Mouse (10 sources):
abnormal CNS synaptic transmission,
abnormal locomotor activation,
abnormal motor capabilities/coordination/movement,
decreased grip strength,
impaired balance,
impaired spatial learning,
increased susceptibility to pharmacologically induced seizures,
limb grasping,
reduced long term potentiation,
weakness
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.