| Monarch Ortholog Phenotypes
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Human (6 sources):
Acute lymphoblastic leukemia,
Hereditary nonpolyposis colorectal carcinoma,
Neoplasm of the stomach,
Renal cell carcinoma,
Transitional cell carcinoma of the bladder,
Uterine leiomyosarcoma
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Mouse (28 sources):
abnormal axon extension,
abnormal dorsal root ganglion morphology,
abnormal facial motor nucleus morphology,
abnormal kidney morphology,
abnormal male germ cell apoptosis,
abnormal ovarian follicle morphology,
abnormal ovarian folliculogenesis,
abnormal phrenic nerve morphology,
abnormal plasma cell morphology,
abnormal proprioceptive neuron morphology,
abnormal seminiferous tubule morphology,
abnormal superior cervical ganglion morphology,
abnormal sympathetic neuron morphology,
arrest of male meiosis,
arrest of spermatogenesis,
decreased apoptosis,
decreased neuron apoptosis,
decreased testis weight,
increased IgG1 level,
increased IgG2a level,
increased mature ovarian follicle number,
increased motor neuron number,
increased sensory neuron number,
increased thymocyte number,
increased transitional stage B cell number,
nervous system phenotype,
renal cast,
uterus hypertrophy
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.