| Monarch Ortholog Phenotypes
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Human (19 sources):
Absence of pubertal development,
Adrenal hypoplasia,
Adrenal insufficiency,
Azoospermia,
Cryptorchidism,
Decreased circulating cortisol level,
Dehydration,
Delayed puberty,
Failure to thrive,
Hyperpigmentation of the skin,
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Mouse (27 sources):
abnormal Sertoli cell development,
abnormal efferent ductules of testis morphology,
abnormal fetal Leydig cell differentiation,
abnormal lipid homeostasis,
abnormal peritubular myoid cell morphology,
abnormal primary sex determination,
abnormal seminiferous tubule epithelium morphology,
abnormal testis cord formation,
absent germ cells,
decreased circulating amylase level,
decreased male germ cell number,
decreased number of peritubular myoid cells,
decreased testis weight,
dilated seminiferous tubules,
disorganized testis cords,
ectopic Leydig cells,
ectopic Sertoli cells,
endocrine/exocrine gland phenotype,
increased Sertoli cell number,
increased bone mineral content,
increased circulating alkaline phosphatase level,
increased testis tumor incidence,
polyovular ovarian follicle,
primary sex reversal,
rete testis obstruction,
retention of the adrenal gland x-zone,
seminiferous tubule degeneration
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.