| Monarch Ortholog Phenotypes
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Human (1 source):
Eczematoid dermatitis
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Mouse (43 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal T-helper 1 physiology,
abnormal T-helper 2 physiology,
abnormal class switch recombination,
abnormal cytotoxic T cell physiology,
abnormal germinal center B cell physiology,
abnormal lymphopoiesis,
abnormal regulatory T cell physiology,
abnormal response to transplant,
decreased CD4-positive, alpha beta T cell number,
decreased IgG1 level,
decreased IgG2a level,
decreased IgG2b level,
decreased T cell proliferation,
decreased circulating interferon-gamma level,
decreased circulating interleukin-4 level,
decreased interferon-gamma secretion,
decreased interleukin-12 secretion,
decreased interleukin-2 secretion,
decreased interleukin-4 secretion,
decreased locomotor activity,
decreased regulatory T cell number,
decreased spleen germinal center number,
decreased susceptibility to experimental autoimmune encephalomyelitis,
decreased susceptibility to type IV hypersensitivity reaction,
enlarged lymph nodes,
enlarged thymus,
focal hair loss,
hunched posture,
increased CD4-positive, alpha beta T cell number,
increased IgG2a level,
increased T cell apoptosis,
increased T cell proliferation,
increased activated T cell number,
increased interferon-gamma secretion,
increased splenocyte proliferation,
increased susceptibility to autoimmune diabetes,
increased susceptibility to autoimmune disorder,
increased susceptibility to experimental autoimmune encephalomyelitis,
increased susceptibility to type I hypersensitivity reaction,
no abnormal phenotype detected,
ruffled hair,
skin lesions
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.