| Monarch Ortholog Phenotypes
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Human (21 sources):
Abnormal liver function tests during pregnancy,
Cirrhosis,
Conjugated hyperbilirubinemia,
Diarrhea,
Elevated circulating hepatic transaminase concentration,
Failure to thrive,
Fat malabsorption,
Fetal distress,
Hearing impairment,
Hepatomegaly,
Increased serum bile acid concentration,
Increased serum bile acid concentration during pregnancy,
Intermittent jaundice,
Intrahepatic cholestasis,
Intrahepatic cholestasis with episodic jaundice,
Jaundice,
Pancreatitis,
Premature birth,
Pruritus,
Severe short stature,
Splenomegaly
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Mouse (31 sources):
abnormal bile salt level,
abnormal bile secretion,
abnormal bone mineralization,
abnormal cochlea morphology,
abnormal cochlear ganglion morphology,
abnormal cued conditioning behavior,
abnormal exploration in a new environment,
abnormal freezing behavior,
abnormal outer hair cell stereociliary bundle morphology,
abnormal sinus arrhythmia,
abnormal startle reflex,
cardiovascular system phenotype,
cochlear inner hair cell degeneration,
cochlear outer hair cell degeneration,
decreased bone mineral content,
decreased exploration in new environment,
decreased grip strength,
decreased heart rate variability,
decreased hematocrit,
decreased hemoglobin content,
degeneration of organ of Corti supporting cells,
enlarged urinary bladder,
impaired cued conditioning behavior,
increased circulating aspartate transaminase level,
increased grip strength,
increased lean body mass,
increased neutrophil cell number,
increased or absent threshold for auditory brainstem response,
increased susceptibility to weight loss,
organ of Corti degeneration,
small seminal vesicle
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.