Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal respiratory system physiology,
Agitation,
Amyotrophic lateral sclerosis,
Anxiety,
Cognitive impairment,
Degeneration of anterior horn cells,
Depression,
Dyspnea,
Emotional lability,
Fatigable weakness of bulbar muscles,
Fatigable weakness of respiratory muscles,
Fatigable weakness of swallowing muscles,
Fatigue,
Generalized muscle weakness,
Laryngospasm,
Muscle spasm,
Nausea and vomiting,
Neurodegeneration,
Pain,
Paralysis,
Respiratory insufficiency,
Skeletal muscle atrophy,
Spasticity,
Xerostomia
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Mouse (97 sources):
abnormal Bruch membrane morphology,
abnormal aerobic respiration,
abnormal basal ganglion morphology,
abnormal behavioral response to amphetamine,
abnormal blood homeostasis,
abnormal brown adipose tissue morphology,
abnormal brown fat cell morphology,
abnormal cellular respiration,
abnormal cerebral cortex morphology,
abnormal choriocapillaris morphology,
abnormal choroid vasculature morphology,
abnormal crypts of Lieberkuhn morphology,
abnormal depression-related behavior,
abnormal fat cell morphology,
abnormal gluconeogenesis,
abnormal lipid homeostasis,
abnormal locomotor behavior,
abnormal melanosome transport,
abnormal mitochondrial physiology,
abnormal myocardial fiber morphology,
abnormal pancreatic beta cell morphology,
abnormal retina pigment epithelium morphology,
abnormal skeletal muscle morphology,
abnormal substantia nigra morphology,
adipose tissue phenotype,
behavior/neurological phenotype,
cardiac hypertrophy,
decreased body fat mass,
decreased body length,
decreased bone mineral content,
decreased brown fat cell size,
decreased cardiac muscle contractility,
decreased cardiac output,
decreased circulating glucose level,
decreased dopamine level,
decreased dopaminergic neuron number,
decreased epididymal fat pad weight,
decreased food intake,
decreased gastrocnemius weight,
decreased grip strength,
decreased heart weight,
decreased lean body mass,
decreased liver triglyceride level,
decreased liver weight,
decreased locomotor activity,
decreased mitochondrial DNA content,
decreased nervous system dopamine level,
decreased oxygen consumption,
decreased percent body fat/body weight,
decreased respiratory quotient,
decreased retroperitoneal fat pad weight,
decreased skeletal muscle weight,
decreased soleus weight,
decreased susceptibility to diet-induced obesity,
decreased triglyceride level,
decreased ventricle muscle contractility,
decreased white fat cell size,
dilated heart left ventricle,
endocrine/exocrine gland phenotype,
growth/size/body region phenotype,
homeostasis/metabolism phenotype,
immune system phenotype,
impaired adaptive thermogenesis,
impaired autophagy,
improved glucose tolerance,
increased adrenal gland weight,
increased basal metabolism,
increased circulating alkaline phosphatase level,
increased circulating glucose level,
increased circulating interleukin-6 level,
increased heart weight,
increased incidence of tumors by chemical induction,
increased insulin sensitivity,
increased interleukin-6 secretion,
increased kidney weight,
increased lung weight,
increased mitochondrial fission,
increased oxygen consumption,
increased pancreatic beta cell mass,
increased percent body fat/body weight,
increased response of heart to induced stress,
increased sensitivity to induced morbidity/mortality,
increased startle reflex,
increased susceptibility to weight gain,
increased thigmotaxis,
increased thymus weight,
increased total body fat amount,
increased tumor growth/size,
limb grasping,
lipofuscinosis,
oxidative stress,
postnatal lethality, incomplete penetrance,
retina macular degeneration,
retina photoreceptor degeneration,
short photoreceptor inner segment,
short photoreceptor outer segment,
spongiform encephalopathy
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View all ortholog results at Monarch
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