| Monarch Ortholog Phenotypes
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Human (41 sources):
Abnormal bleeding,
Abnormality of movement,
Abnormality of the ovary,
Albuminuria,
Aminoaciduria,
Ataxia,
Cataract,
Cirrhosis,
Decreased fertility in females,
Decreased liver function,
Diarrhea,
Dysarthria,
Failure to thrive,
Feeding difficulties,
Gait disturbance,
Galactosuria,
Hemolytic anemia,
Hepatic failure,
Hepatomegaly,
Hyperchloremic metabolic acidosis,
Hypergalactosemia,
Hypergonadotropic hypogonadism,
Hypoglycemia,
Impairment of galactose metabolism,
Increased level of galactitol in plasma,
Increased level of galactitol in red blood cells,
Increased level of galactitol in urine,
Increased level of galactonate in red blood cells,
Intellectual disability,
Jaundice,
Lethargy,
Metabolic acidosis,
Nausea and vomiting,
Osteoporosis,
Premature ovarian insufficiency,
Sepsis,
Speech apraxia,
Speech articulation difficulties,
Tremor,
Vomiting,
Weight loss
[+]
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Mouse (9 sources):
abnormal Purkinje cell morphology,
abnormal cerebellum external granule cell layer morphology,
abnormal corpus luteum morphology,
abnormal galactose homeostasis,
abnormal ovarian follicle number,
decreased litter size,
increased sensitivity to induced morbidity/mortality,
oxidative stress,
reduced female fertility
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.