| Monarch Ortholog Phenotypes
|
Human (49 sources):
Abnormality of epiphysis morphology,
Abnormality of the dentition,
Abnormality of the head,
Abnormality of the lower limb,
Abnormality of the metaphysis,
Abnormality of the ulna,
Abnormality of ulnar metaphysis,
Aplasia/Hypoplasia of the radius,
Bowing of the long bones,
Carious teeth,
Coxa vara,
Delayed skeletal maturation,
Disproportionate short stature,
Femoral bowing,
Flared iliac wing,
Flared metaphysis,
Flared, irregular rib ends,
Flattened epiphysis,
Gait disturbance,
Genu valgum,
Genu varum,
Hip dysplasia,
Hyperlordosis,
Irregular sclerotic endplates,
Joint stiffness,
Limitation of joint mobility,
Limited elbow extension,
Metaphyseal chondrodysplasia,
Metaphyseal cupping,
Metaphyseal dysplasia,
Metaphyseal sclerosis,
Metaphyseal widening,
Motor delay,
Osteoarthritis,
Pear-shaped vertebrae,
Platyspondyly,
Progressive leg bowing,
Radial bowing,
Reduced bone mineral density,
Rhizomelia,
Scoliosis,
Short lower limbs,
Short stature,
Skeletal dysplasia,
Small epiphyses,
Spondyloepimetaphyseal dysplasia,
Tibial bowing,
Ulnar bowing,
Waddling gait
[+]
|
|
Mouse (11 sources):
abnormal bone healing,
abnormal cartilage development,
abnormal long bone hypertrophic chondrocyte zone,
decreased angiogenesis,
decreased cell proliferation,
delayed bone ossification,
delayed wound healing,
increased long bone epiphyseal plate size,
increased trabecular bone mass,
increased width of hypertrophic chondrocyte zone,
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.