| Monarch Ortholog Phenotypes
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Human (42 sources):
Abnormal foot morphology,
Abnormal thorax morphology,
Abnormality of metabolism/homeostasis,
Anteverted nares,
Ascites,
Ataxia,
Athetosis,
Cardiomegaly,
Cerebral atrophy,
Coarse facial features,
Congestive heart failure,
Conjugated hyperbilirubinemia,
Delayed speech and language development,
Dysarthria,
Epicanthus,
Exotropia,
Failure to thrive,
Fair hair,
Generalized hypotonia,
Gingival overgrowth,
Global developmental delay,
Growth delay,
Hepatomegaly,
High palate,
Hydrocephalus,
Hydrops fetalis,
Hypopigmentation of the skin,
Hypotonia,
Inability to walk,
Intellectual disability,
J-shaped sella turcica,
Metaphyseal irregularity,
Nephrotic syndrome,
Nystagmus,
Osteopenia,
Premature birth,
Ptosis,
Seizure,
Spasticity,
Splenomegaly,
Thickened calvaria,
Vacuolated lymphocytes
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Mouse (14 sources):
abnormal cell morphology,
abnormal locomotor behavior,
abnormal myelin sheath morphology,
abnormal optic tract morphology,
behavioral despair,
brain vacuoles,
decreased body size,
decreased exploration in new environment,
decreased oligodendrocyte progenitor number,
environmentally induced seizures,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.