ptpn22 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (0)

XB-GENEPAGE-853932

Gene Symbol: ptpn22 Gene Name: protein tyrosine phosphatase non-receptor type 22

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (43 sources): abnormal B cell activation, abnormal Peyer's patch germinal center morphology, abnormal T cell activation, abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal dendritic cell physiology, abnormal double-positive T cell morphology, abnormal thymocyte activation, abnormal thymus morphology, autoimmune response, decreased B cell apoptosis, decreased follicular B cell number, decreased mature B cell number, enlarged lymph nodes, enlarged thymus, immune system phenotype, increased B cell proliferation, increased CD4-positive, alpha beta T cell number, increased CD4-positive, alpha-beta memory T cell number, increased CD8-positive, alpha-beta T cell number, increased IgG1 level, increased IgG2a level, increased IgG3 level, increased T cell proliferation, increased anti-double stranded DNA antibody level, increased anti-insulin autoantibody level, increased autoantibody level, increased dendritic cell number, increased double-positive T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased follicular B cell number, increased germinal center B cell number, increased interleukin-12 secretion, increased interleukin-2 secretion, increased memory T cell number, increased physiological sensitivity to xenobiotic, increased regulatory T cell number, increased spleen germinal center number, increased spleen germinal center size, increased transitional stage T1 B cell number, premature death, spleen hyperplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (43 sources): abnormal B cell activation, abnormal Peyer's patch germinal center morphology, abnormal T cell activation, abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal dendritic cell physiology, abnormal double-positive T cell morphology, abnormal thymocyte activation, abnormal thymus morphology, autoimmune response, [+]