| Monarch Ortholog Phenotypes
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Human (14 sources):
Autoimmune hemolytic anemia,
Autoimmune thrombocytopenia,
Autoimmunity,
Hemiparesis,
Hemolytic anemia,
Hepatitis,
Lymphadenopathy,
Lymphopenia,
Moderate global developmental delay,
Recurrent otitis media,
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Mouse (24 sources):
abnormal CD4-positive T cell differentiation,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal antigen presentation,
abnormal cytotoxic T cell physiology,
abnormal immune system organ morphology,
abnormal level of surface class I molecules,
abnormal lymphocyte physiology,
abnormal splenic cell ratio,
decreased double-positive T cell number,
disheveled coat,
early cellular replicative senescence,
enlarged lymph nodes,
focal hair loss,
hematopoietic system phenotype,
increased T cell apoptosis,
increased anti-nuclear antigen antibody level,
increased autoantibody level,
increased double-negative T cell number,
increased memory T cell number,
increased single-positive T cell number,
increased spleen red pulp amount,
premature aging,
premature death,
thymus atrophy
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.