| Monarch Ortholog Phenotypes
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Human (8 sources):
Abnormality of the outer ear,
Buphthalmos,
Cataract,
Microcornea,
Microphthalmia,
Ocular anterior segment dysgenesis,
Ocular hypertension,
Sclerocornea
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Mouse (30 sources):
abnormal anxiety-related response,
abnormal corneal stroma morphology,
abnormal extracellular matrix morphology,
abnormal eye posterior chamber morphology,
abnormal iridocorneal angle,
abnormal lens development,
abnormal lens epithelium morphology,
abnormal lens fiber morphology,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal retina inner limiting membrane morphology,
absent eye anterior chamber,
belly spot,
corneal-lenticular stalk,
decreased cell proliferation,
decreased corneal epithelium thickness,
decreased exploration in new environment,
decreased eye anterior chamber depth,
decreased retina ganglion cell number,
decreased thigmotaxis,
disorganized secondary lens fibers,
eye inflammation,
fused cornea and lens,
increased corneal stroma thickness,
increased vertical activity,
kinked tail,
preweaning lethality, incomplete penetrance,
retina gliosis,
ruptured lens capsule,
vitreous body deposition
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.