top2b Phenotypes

Phenotypes

XB-GENEPAGE-940715

Gene Symbol: top2b Gene Name: DNA topoisomerase II beta

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: top2b assayed (8 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (30 sources): abnormal cerebral cortex morphology, abnormal embryonic/fetal subventricular zone morphology, abnormal hippocampus granule cell layer, abnormal hippocampus pyramidal cell layer, abnormal innervation pattern to muscle, abnormal motor capabilities/coordination/movement, abnormal motor neuron innervation pattern, abnormal photoreceptor outer segment morphology, abnormal retina cone cell morphology, abnormal retina cone cell outer segment morphology, abnormal retina outer limiting membrane morphology, abnormal retina outer plexiform layer morphology, abnormal retina pigment epithelium morphology, abnormal retina rod cell morphology, abnormal retina rod cell outer segment morphology, abnormal spine curvature, abnormal stratification in cerebral cortex, abnormal telencephalon development, absent subplate, decreased body size, decreased brain size, decreased embryo size, disorganized cortical plate, neonatal lethality, complete penetrance, no abnormal phenotype detected, photoreceptor outer segment degeneration, retina cone cell degeneration, retina photoreceptor degeneration, small olfactory bulb, thin retina outer nuclear layer [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (30 sources): abnormal cerebral cortex morphology, abnormal embryonic/fetal subventricular zone morphology, abnormal hippocampus granule cell layer, abnormal hippocampus pyramidal cell layer, abnormal innervation pattern to muscle, abnormal motor capabilities/coordination/movement, abnormal motor neuron innervation pattern, abnormal photoreceptor outer segment morphology, abnormal retina cone cell morphology, abnormal retina cone cell outer segment morphology, [+]