Arterial stenosis, Atherosclerosis, Atlantoaxial dislocation, Atrial fibrillation, Bone cyst, Bradycardia, Broad foot, Cardiomyopathy, Cirrhosis, Clitoral hypertrophy, Congestive heart failure, Cystic angiomatosis of bone, Decreased circulating IgA level, Decreased fertility in females, Decreased response to growth hormone stimulation test, Decreased serum leptin, Delayed skeletal maturation, Diabetes mellitus, Dysmenorrhea, Elevated circulating growth hormone concentration, Elevated circulating hepatic transaminase concentration, Exercise-induced myalgia, Failure to thrive, Flexion contracture, Generalized hirsutism, Generalized muscular appearance from birth, Glomerulopathy, Hepatic failure, Hepatic steatosis, Hepatomegaly, Hirsutism, Hyperhidrosis, Hyperinsulinemia, Hyperlordosis, Hypertriglyceridemia, Hypertrophic cardiomyopathy, Immunodeficiency, Insulin resistance, Insulin-resistant diabetes mellitus at puberty, Intellectual disability, Labial hypertrophy, Large hands, Lipoatrophy, Lipodystrophy, Long foot, Loss of subcutaneous adipose tissue in limbs, Macrotia, Mandibular prognathia, Muscle stiffness, Muscle weakness, Myalgia, Myocardial infarction, Myopathy, Nephrolithiasis, Nephropathy, Oligomenorrhea, Osteopenia, Osteoporosis, Palpitations, Pancreatitis, Peripheral neuropathy, Polycystic ovaries, Polyphagia, Precocious puberty, Progressive proximal muscle weakness, Prolonged QTc interval, Prominent supraorbital ridges, Prominent umbilicus, Pulmonary arterial hypertension, Pyloric stenosis, Recurrent fractures, Recurrent infections, Reduced intraabdominal adipose tissue, Reduced intrathoracic adipose tissue, Reduced subcutaneous adipose tissue, Renal insufficiency, Scoliosis, Secondary amenorrhea, Skeletal muscle hypertrophy, Spinal rigidity, Splenomegaly, Tall stature, Thickened skin, Triangular face, Umbilical hernia, Ventricular hypertrophy, Ventriculomegaly

decreased body size, decreased brown adipose tissue amount, decreased circulating free fatty acids level, decreased locomotor activity, decreased percent body fat/body weight, decreased respiratory quotient, decreased survivor rate, decreased white adipose tissue amount, decreased white fat cell number, decreased white fat cell size, femur fracture, granulomatous inflammation, homeostasis/metabolism phenotype, improved glucose tolerance, increased carbon dioxide production, increased circulating glucose level, increased fluid intake, increased food intake, increased kidney weight, increased liver triglyceride level, increased liver weight, increased oxygen consumption, increased pancreatic beta cell mass, increased pancreatic beta cell number, increased spleen weight, microvesicular hepatic steatosis, pale liver, postnatal lethality, incomplete penetrance, premature death, reduced enamel thickness, rough coat