| Monarch Ortholog Phenotypes
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Human (29 sources):
Agammaglobulinemia,
Arthritis,
Bronchiectasis,
Cellulitis,
Chronic otitis media,
Conjunctivitis,
Cough,
Dehydration,
Diarrhea,
Epicanthus,
Failure to thrive,
Fatigue,
Fever,
Hepatitis,
High palate,
Hypertelorism,
Immunodeficiency,
Malabsorption,
Meningitis,
Neutropenia,
Osteomyelitis,
Recurrent infections,
Recurrent respiratory infections,
Recurrent skin infections,
Sepsis,
Sinusitis,
Skin rash,
Verrucae,
obsolete External ear malformation
[+]
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Mouse (29 sources):
abnormal B cell activation,
abnormal B cell apoptosis,
abnormal immature B cell morphology,
abnormal mature B cell morphology,
abnormal plasma cell differentiation,
abnormal pre-B cell morphology,
absent B-1a cells,
absent B-1b cells,
arrested B cell differentiation,
cardiovascular system phenotype,
decreased B cell proliferation,
decreased B-1a cell number,
decreased IgG3 level,
decreased follicular B cell number,
decreased immature B cell number,
decreased marginal zone B cell number,
decreased mature B cell number,
decreased pre-B cell number,
decreased splenocyte number,
decreased transitional stage B cell number,
immune system phenotype,
increased B cell apoptosis,
increased CD4-positive, alpha beta T cell number,
increased CD8-positive, alpha-beta T cell number,
increased anti-double stranded DNA antibody level,
increased mature B cell number,
increased pre-B cell number,
increased pro-B cell number,
increased tumor incidence
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.