Decreased circulating IgA level, Decreased circulating IgG level, Decreased proportion of CD3-positive T cells, Desquamation of skin soon after birth, Diarrhea, Dry skin, Edema, Eosinophilia, Erythroderma, Failure to thrive, Fever, Genital ulcers, Hashimoto thyroiditis, Hepatomegaly, Hypoplasia of the thymus, Hypoproteinemia, Hypothyroidism, Juvenile rheumatoid arthritis, Leukocytosis, Lymph node hypoplasia, Lymphadenopathy, Lymphoma, Nephrotic syndrome, Oral ulcer, Otitis media, Panhypogammaglobulinemia, Pneumonia, Pruritus, Recurrent aphthous stomatitis, Recurrent bacterial infections, Recurrent fungal infections, Recurrent gastroenteritis, Recurrent mycobacterial infections, Recurrent opportunistic infections, Recurrent upper and lower respiratory tract infections, Recurrent upper respiratory tract infections, Recurrent viral infections, Sepsis, Severe B lymphocytopenia, Severe combined immunodeficiency, Short toe, Skin rash, Splenomegaly, Thickened skin, Thrombocytopenia, Thyroiditis, Verrucae, Vitiligo, obsolete Hypotrichosis

absent thymus cortex, arrested B cell differentiation, arrested T cell differentiation, chromosomal instability, decreased B cell proliferation, decreased B-1 B cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased DN1 thymic pro-T cell number, decreased DN4 thymocyte number, decreased NK T cell number, decreased T cell proliferation, decreased body size, decreased double-positive T cell number, decreased mature B cell number, decreased pre-B cell number, decreased response to antigen, decreased single-positive T cell number, decreased splenocyte number, decreased systemic arterial systolic blood pressure, decreased thymocyte number, decreased thymus weight, immune system phenotype, impaired humoral immune response, increased NK cell number, increased cellular sensitivity to gamma-irradiation, increased cellular sensitivity to ionizing radiation, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased macrophage cell number, increased neutrophil cell number, increased pro-B cell number, induced chromosome breakage, small lymph nodes, small spleen