| Monarch Ortholog Phenotypes
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Human (9 sources):
Decreased circulating IgA level,
Decreased circulating IgG level,
Epididymitis,
Immunodeficiency,
Impaired Ig class switch recombination,
Increased circulating IgM level,
Lymphadenopathy,
Recurrent bacterial infections,
Recurrent upper and lower respiratory tract infections
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Mouse (14 sources):
abnormal base-excision repair,
abnormal class switch recombination,
abnormal somatic hypermutation frequency,
decreased IgG3 level,
enlarged lymph nodes,
enlarged thymus,
increased B cell derived lymphoma incidence,
increased cellular sensitivity to oxidative stress,
increased sensitivity to induced cell death,
increased susceptibility to ischemic brain injury,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.