dhfr Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-975266

Gene Symbol: dhfr Gene Name: dihydrofolate reductase

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased apoptosis in head (3 sources), abnormal eye morphology (1 source), abnormal histone methylation (1 source), abnormal mouth morphology (1 source), abnormal small intestine morphology (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the intercanthal region (1 source), decreased size of the mouth (1 source), obsolete abnormal histone phosphorylation (1 source), obsolete abnormally edematous pericardium (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

increased apoptosis in head (3 sources), abnormal eye morphology (1 source), abnormal histone methylation (1 source), abnormal mouth morphology (1 source), abnormal small intestine morphology (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the intercanthal region (1 source), decreased size of the mouth (1 source), obsolete abnormal histone phosphorylation (1 source), obsolete abnormally edematous pericardium (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dhfr MO (6 sources), Xla Wt + dhfr MO (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (18 sources): Ataxia, Cerebellar hypoplasia, Cerebral atrophy, Delayed myelination, Eyelid myoclonus, Feeding difficulties, Generalized hypotonia, Generalized non-motor (absence) seizure, Global developmental delay, Hepatomegaly, Hypotonia, Jaundice, Megaloblastic anemia, Pallor, Pancytopenia, Poor head control, Secondary microcephaly, Thrombocytopenia [+]
Mouse (26 sources): abnormal DNA methylation, abnormal embryo size, abnormal folic acid level, abnormal forebrain development, abnormal hemopoiesis, abnormal hindbrain development, abnormal mean corpuscular hemoglobin, abnormal midbrain development, decreased circulating bilirubin level, decreased common myeloid progenitor cell number, decreased embryo size, decreased erythrocyte cell number, decreased fetal size, decreased granulocyte monocyte progenitor cell number, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, decreased vasodilation, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage, homeostasis/metabolism phenotype, increased erythrocyte cell number, increased nucleated erythrocyte cell number, lethality during fetal growth through weaning, complete penetrance, liver hypoplasia, pale liver, preweaning lethality, complete penetrance [+]
View all ortholog results at Monarch