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XB-GENEPAGE-978274
dlg5 discs large homolog 5
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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increased size of the proximal tubule (3 sources), abnormal kidney morphology (2 sources), abnormally decreased number of cilium in the pronephric kidney (2 sources), abnormal brain ventricle morphology (1 source), abnormal establishment of apical/basal cell polarity (1 source), abnormally decreased number of multiciliated epidermal cell (1 source), abnormally increased number of goblet cell (1 source) |
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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Manual annotations: dlg5 manipulated (3 sources) |
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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ciliopathy (4AP sources, 2 EP sources), communicating hydrocephalus (1AP source) |
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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Xtr Wt + dlg5 MO (9 sources), Xtr Wt + dlg5 CRISPR (2 sources), Xtr Wt + Hsa.DLG5Arg249Trp (1 source) |
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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Mouse (12 sources): abnormal cerebral aqueduct morphology, abnormal ependyma morphology, abnormal kidney collecting duct morphology, abnormal neuron differentiation, abnormal papillary duct morphology, abnormal postnatal subventricular zone morphology, abnormal renal tubule morphology, abnormal third ventricle morphology, dilated kidney collecting duct, increased brain size, [+] |