mecom Phenotypes

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Phenotypes

Gene Literature (11)

Nucleotides (117)

Interactants (148)

XB-GENEPAGE-980194

Gene Symbol: mecom Gene Name: MDS1 and EVI1 complex locus

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: mecom assayed (4 sources)
Computed annotations: mecom assayed (8 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (13 sources): Amegakaryocytic thrombocytopenia, Anemia, Clinodactyly of the 5th finger, Congenital thrombocytopenia, Finger syndactyly, Hip dysplasia, Hydrocele testis, Limited pronation/supination of forearm, Neutropenia, Overlapping fingers, Radioulnar synostosis, Sensorineural hearing impairment, Thrombocytopenia [+]
Mouse (76 sources): abnormal amnion morphology, abnormal bone marrow cell morphology/development, abnormal common myeloid progenitor cell morphology, abnormal cranial ganglia morphology, abnormal craniofacial morphology, abnormal diencephalon morphology, abnormal fetal liver hematopoietic progenitor cell morphology, abnormal heart looping, abnormal hematopoietic precursor cell number, abnormal hematopoietic stem cell morphology, abnormal hematopoietic stem cell physiology, abnormal immune system organ morphology, abnormal limb development, abnormal liver bud morphology, abnormal locomotor activation, abnormal mesonephros morphology, abnormal miscarriage rate, abnormal myotome development, abnormal neutrophil differentiation, abnormal pinna reflex, abnormal spinal nerve morphology, abnormal startle reflex, abnormal superior glossopharyngeal ganglion morphology, abnormal superior vagus ganglion morphology, abnormal tympanic membrane morphology, abnormal vitelline vasculature morphology, absent hindlimb buds, absent myotome, absent paraxial mesoderm, absent sclerotome, deafness, decreased body size, decreased common myeloid progenitor cell number, decreased embryo size, decreased erythrocyte cell number, decreased hematopoietic stem cell number, decreased hemoglobin content, decreased prepulse inhibition, distended pericardium, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, enlarged pericardium, hearing/vestibular/ear phenotype, hematopoietic system phenotype, immune system phenotype, incomplete somite formation, increased circulating amylase level, increased lean body mass, increased sensitivity to xenobiotic induced morbidity/mortality, increased startle reflex, increased susceptibility to otitis media, increased total body fat amount, lethality throughout fetal growth and development, complete penetrance, lethality throughout fetal growth and development, incomplete penetrance, lethality, complete penetrance, limb grasping, middle ear effusion, middle ear polyps, nervous system phenotype, no abnormal phenotype detected, pale placenta, pale yolk sac, perinatal lethality, complete penetrance, perinatal lethality, incomplete penetrance, pharyngeal arch hypoplasia, postnatal lethality, complete penetrance, preweaning lethality, complete penetrance, pulmonary vascular congestion, respiratory system inflammation, skin edema, small embryonic telencephalon, small forelimb buds, small trigeminal ganglion, trabecula carnea hypoplasia, tympanic membrane perforation, weakness [+]
View all ortholog results at Monarch