gck Phenotypes

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Phenotypes

Gene Literature (19)

Nucleotides (70)

Interactants (108)

XB-GENEPAGE-981991

Gene Symbol: gck Gene Name: glucokinase (hexokinase 4)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: gck assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (84 sources): Abnormal C-peptide level, Abnormal heart morphology, Abnormal insulin level, Abnormal nervous system physiology, Abnormal oral glucose tolerance, Abnormality of the autonomic nervous system, Abnormality of the ear, Abnormality of the genitourinary system, Abnormality of the immune system, Abnormality of the kidney, Abnormality of the upper urinary tract, Anteverted nares, Apraxia, Arthrogryposis multiplex congenita, Ataxia, Axial hypotonia, Beta-cell dysfunction, Bilateral ptosis, Bilateral tonic-clonic seizure, Clinodactyly, Coma, Contractures of the joints of the lower limbs, Decreased waist to hip ratio, Dehydration, Diabetes mellitus, Downturned corners of mouth, Elevated hemoglobin A1c, Exocrine pancreatic insufficiency, Failure to thrive, Fasting hyperinsulinemia, Fatigue, Generalized myoclonic seizure, Global developmental delay, Glucose intolerance, Glycosuria, Hand tremor, Hearing impairment, Hepatocellular adenoma, Hyperglycemia, Hyperinsulinemic hypoglycemia, Hypoglycemic coma, Hypoglycemic seizures, Hypoinsulinemia, Hypoketotic hypoglycemia, Hypotonia, Hypovolemia, Hypsarrhythmia, Insulin resistance, Insulin-resistant diabetes mellitus, Intellectual disability, Intellectual disability, severe, Intrauterine growth retardation, Ketoacidosis, Ketonuria, Large for gestational age, Limb joint contracture, Long philtrum, Maturity-onset diabetes of the young, Moderate albuminuria, Motor delay, Muscle weakness, Neonatal hypoglycemia, Neonatal insulin-dependent diabetes mellitus, Nephropathy, Neurodevelopmental delay, Obesity, Overweight, Pancreatic hypoplasia, Peripheral axonal neuropathy, Peripheral neuropathy, Prominent metopic ridge, Ptosis, Radial deviation of finger, Recurrent hypoglycemia, Reduced pancreatic beta cells, Renal cyst, Renal tubular dysfunction, Retinopathy, Seizure, Short nose, Small for gestational age, Transient neonatal diabetes mellitus, Type II diabetes mellitus, Weight loss [+]
Mouse (30 sources): abnormal circulating alkaline phosphatase level, abnormal circulating cholesterol level, abnormal circulating fructosamine level, abnormal heart echocardiography feature, abnormal insulin secretion, abnormal mitochondrial crista morphology, abnormal pancreatic beta cell morphology, abnormal pancreatic beta cell physiology, abnormal pancreatic islet morphology, cardiac fibrosis, decreased circulating glucose level, decreased glucokinase activity, decreased glycogen level, decreased insulin secretion, decreased liver glycogen level, decreased pancreatic beta cell mass, embryonic lethality during organogenesis, incomplete penetrance, endocrine/exocrine gland phenotype, homeostasis/metabolism phenotype, increased circulating alkaline phosphatase level, increased circulating fructosamine level, increased circulating glucose level, increased fasting circulating glucose level, microvesicular hepatic steatosis, neonatal lethality, incomplete penetrance, postnatal lethality, postnatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, prolonged QRS complex duration, small pancreatic islets [+]
View all ortholog results at Monarch