Gonadotropin deficiency, Growth delay, Hyperinsulinemia, Hypoglycemic seizures, Hypogonadotropic hypogonadism, Hypopigmentation of the skin, Increased adipose tissue, Malabsorption, Obesity, Pituitary hypothyroidism, Polyphagia, Primary amenorrhea, Reactive hypoglycemia, Red hair, Villous atrophy

abnormal spleen white pulp morphology, abnormal vitreous body morphology, decreased NK T cell number, decreased adrenocorticotropin level, decreased body length, decreased circulating growth hormone level, decreased follicular dendritic cell number, decreased locomotor activity, decreased mean corpuscular volume, decreased mean systemic arterial blood pressure, decreased skeletal muscle mass, decreased testis weight, embryonic lethality before implantation, complete penetrance, homeostasis/metabolism phenotype, increased circulating interferon-gamma level, increased circulating interleukin-1 beta level, increased circulating interleukin-10 level, increased circulating interleukin-12 level, increased circulating interleukin-6 level, increased circulating tumor necrosis factor level, increased interleukin-1 beta secretion, increased sensitivity to xenobiotic induced morbidity/mortality, increased skeletal muscle mass, increased susceptibility to diet-induced obesity, increased susceptibility to endotoxin shock, increased white adipose tissue amount, intermingled spleen red and white pulp, persistence of hyaloid vascular system, postnatal lethality, incomplete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, incomplete penetrance, reduced fertility, slow postnatal weight gain, transmission ratio distortion