dock8 Phenotypes

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Phenotypes

Gene Literature (0)

Nucleotides (107)

Interactants (85)

XB-GENEPAGE-987087

Gene Symbol: dock8 Gene Name: dedicator of cytokinesis 8

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (27 sources): Anal canal squamous carcinoma, Asthma, Atopic dermatitis, B lymphocytopenia, Cerebral vasculitis, Chronic otitis media, Eczematoid dermatitis, Eosinophilia, Hemiplegia, Increased circulating IgE level, Neoplasm, Onychomycosis, Pneumonia, Recurrent bacterial infections, Recurrent bacterial skin infections, Recurrent candida infections, Recurrent fungal infections, Recurrent respiratory infections, Recurrent sinopulmonary infections, Recurrent sinusitis, Recurrent viral infections, Skin ulcer, Squamous cell carcinoma, Squamous cell carcinoma of the vulva, Subarachnoid hemorrhage, T lymphocytopenia, Verrucae [+]
Mouse (23 sources): abnormal CD4-positive T cell differentiation, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal T cell differentiation, abnormal cellular extravasation, abnormal dendritic cell physiology, abnormal humoral immune response, absent marginal zone B cells, decreased B-1 B cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased T cell proliferation, decreased activated T cell number, decreased follicular dendritic cell number, decreased germinal center B cell number, decreased marginal zone B cell number, decreased spleen germinal center size, decreased susceptibility to experimental autoimmune encephalomyelitis, impaired humoral immune response, increased CD4-positive, alpha beta T cell number, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number [+]
View all ortholog results at Monarch