prdm16 Phenotypes

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Phenotypes

Gene Literature (9)

Nucleotides (76)

Interactants (96)

XB-GENEPAGE-991669

Gene Symbol: prdm16 Gene Name: PR domain 16

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: prdm16 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (16 sources): Abnormal left ventricle morphology, Abnormal left ventricular function, Abnormality of neutrophils, Arrhythmia, Congestive heart failure, Dilated cardiomyopathy, EMG abnormality, Eczematoid dermatitis, Elevated circulating creatine kinase concentration, Headache, Left ventricular noncompaction, Lipoatrophy, Mitral regurgitation, Myopathy, Palmoplantar keratoderma, Sensorineural hearing impairment [+]
Mouse (48 sources): abnormal adipose tissue distribution, abnormal adipose tissue physiology, abnormal brown adipose tissue morphology, abnormal brown adipose tissue thermogenesis, abnormal cellular respiration, abnormal choroid plexus morphology, abnormal interscapular fat pad morphology, abnormal mandible morphology, abnormal nasal bone morphology, abnormal oxygen consumption, abnormal palatal shelf elevation, abnormal snout morphology, abnormal sublingual duct morphology, abnormal sublingual gland morphology, abnormal submandibular duct morphology, decreased adipocyte glucose uptake, decreased body fat mass, decreased body length, decreased brown fat lipid droplet number, decreased lean body mass, decreased mitochondrial DNA content, impaired adaptive thermogenesis, improved glucose tolerance, increased brown fat cell lipid droplet size, increased interscapular fat pad weight, increased liver triglyceride level, increased macrophage cell number, increased respiratory quotient, increased subcutaneous adipose tissue amount, increased susceptibility to weight gain, increased total body fat amount, mandible hypoplasia, narrow maxilla, narrow snout, neonatal lethality, complete penetrance, no abnormal phenotype detected, perinatal lethality, complete penetrance, pointed snout, premature bone ossification, prenatal lethality, incomplete penetrance, short Meckel's cartilage, short maxilla, small lung, small mandible, submandibular gland hypoplasia, submucous cleft palate, ventricular hypoplasia, whitened brown adipose tissue morphology [+]
View all ortholog results at Monarch