Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
1994 May 01;145:2871-82. doi: 10.1128/mcb.14.5.2871-2882.1994.
Show Gene links
Show Anatomy links
xUBF, an RNA polymerase I transcription factor, binds crossover DNA with low sequence specificity.
Hu CH
,
McStay B
,
Jeong SW
,
Reeder RH
.
???displayArticle.abstract???
Xenopus UBF (xUBF) is a transcription factor for RNA polymerase I which contains multiple DNA-binding motifs. These include a short basic region adjacent to a dimer motif plus five high-mobility-group (HMG) boxes. All of these DNA-binding motifs exhibit low sequence specificity, whether assayed singly or together. In contrast, the HMG boxes recognize DNA structure that is formed when two double helices are crossed over each other. HMG box 1, in particular, requires association of two double helices before it will bind and, either by itself or in the context of the intact protein, will loop DNA and organize it into higher-order structures. We discuss how this mode of binding affects the function of xUBF as a transcription factor.
Bachvarov,
The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes.
1991, Pubmed,
Xenbase
Bachvarov,
The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes.
1991,
Pubmed
,
Xenbase
Bell,
Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.
1988,
Pubmed
Bell,
Assembly of alternative multiprotein complexes directs rRNA promoter selectivity.
1990,
Pubmed
Choe,
In vitro definition of the yeast RNA polymerase I promoter.
1992,
Pubmed
Comai,
The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1.
1992,
Pubmed
Cormack,
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells.
1992,
Pubmed
Ferrari,
SRY, like HMG1, recognizes sharp angles in DNA.
1992,
Pubmed
Fisher,
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein.
1992,
Pubmed
Guimond,
Variants of the Xenopus laevis ribosomal transcription factor xUBF are developmentally regulated by differential splicing.
1992,
Pubmed
,
Xenbase
Hamada,
Hierarchy of binding sites for chromosomal proteins HMG 1 and 2 in supercoiled deoxyribonucleic acid.
1985,
Pubmed
Hisatake,
Cloning and structural analysis of cDNA and the gene for mouse transcription factor UBF.
1991,
Pubmed
Jantzen,
Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.
1990,
Pubmed
Jantzen,
Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription.
1992,
Pubmed
,
Xenbase
Kerrigan,
Periodic binding of individual core histones to DNA: inadvertent purification of the core histone H2B as a putative enhancer-binding factor.
1992,
Pubmed
Kuhn,
Dual role of the nucleolar transcription factor UBF: trans-activator and antirepressor.
1992,
Pubmed
Kunkel,
Rapid and efficient site-specific mutagenesis without phenotypic selection.
1987,
Pubmed
Leblanc,
Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction.
1993,
Pubmed
,
Xenbase
Lilley,
DNA--protein interactions. HMG has DNA wrapped up.
1992,
Pubmed
Maeda,
Mouse rRNA gene transcription factor mUBF requires both HMG-box1 and an acidic tail for nucleolar accumulation: molecular analysis of the nucleolar targeting mechanism.
1992,
Pubmed
McStay,
A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter.
1986,
Pubmed
,
Xenbase
McStay,
xUBF and Rib 1 are both required for formation of a stable polymerase I promoter complex in X. laevis.
1991,
Pubmed
,
Xenbase
McStay,
xUBF contains a novel dimerization domain essential for RNA polymerase I transcription.
1991,
Pubmed
,
Xenbase
O'Mahony,
Identification of two forms of the RNA polymerase I transcription factor UBF.
1991,
Pubmed
O'Mahony,
Differential phosphorylation and localization of the transcription factor UBF in vivo in response to serum deprivation. In vitro dephosphorylation of UBF reduces its transactivation properties.
1992,
Pubmed
O'Mahony,
Analysis of the phosphorylation, DNA-binding and dimerization properties of the RNA polymerase I transcription factors UBF1 and UBF2.
1992,
Pubmed
Parisi,
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.
1991,
Pubmed
Pikaard,
The Xenopus ribosomal gene enhancers bind an essential polymerase I transcription factor, xUBF.
1989,
Pubmed
,
Xenbase
Putnam,
Cooperative binding of the Xenopus RNA polymerase I transcription factor xUBF to repetitive ribosomal gene enhancers.
1992,
Pubmed
,
Xenbase
Roussel,
Localization of the RNA polymerase I transcription factor hUBF during the cell cycle.
1993,
Pubmed
Schultz,
Variants of the TATA-binding protein can distinguish subsets of RNA polymerase I, II, and III promoters.
1992,
Pubmed
Simpson,
Nucleosome positioning: occurrence, mechanisms, and functional consequences.
1991,
Pubmed
Studier,
Use of T7 RNA polymerase to direct expression of cloned genes.
1990,
Pubmed
Travis,
LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].
1991,
Pubmed
Voit,
The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation.
1992,
Pubmed
Weir,
Structure of the HMG box motif in the B-domain of HMG1.
1993,
Pubmed
Zechiedrich,
Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers.
1990,
Pubmed
