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New evidence supports the idea of a nonmicrotubule spindle matrix, but the debate about the reality of this structure continues.
Figure 1. New evidence for a possible spindle matrix. Speckles of polymerized tubulin (top) move over time (top to bottom), whereas speckles of the kinesin motor Eg5 (bottom) stay stationary relative to the spindle. Thus, the Eg5 may be tethered by a spindle matrix.
Figure 2. Skeletor (red) forms a structure in the nucleus even before the formation of an extensive microtubule-based spindle (green). See http://www.jcb.org/cgi/content/full/151/7/1401/DC1 for related videos.
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